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Observe for signs and symptoms of heart failure.Certain drugs may affect glucose metabolism, requiring insulin dose adjustment and close monitoring of blood glucose.Other adverse reactions commonly associated with Apidra Solostar include injection site reactions, lipodystrophy, pruritus, and rash., beta-blockers, clonidine, guanethidine, and reserpine).Apidra Solostar for subcutaneous injection should not be mixed with insulins other than NPH. Do NOT reuse needles.Apidra Solostar is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Apidra Solostar or any of its excipients.Severe life-threatening, generalized allergy, including anaphylaxis, can occur.When used as a mealtime insulin, the dose of Apidra Solostar should be given within 15 minutes before or within 20 minutes after starting a meal.Closely monitor blood glucose in all patients treated with insulin. All insulins, including Apidra Solostar, can cause hypokalemia, which if untreated, may be serious.Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs) with insulin. The signs of hypoglycemia may be reduced in patients taking anti-adrenergic drugs (e. As with all insulin preparations, the time course of Apidra Solostar action may vary by individual or at different times in the same individual and is dependent on many conditions, including the site of injection, local blood supply, or local temperature. Do not mix Apidra Solostar with any insulin when used in the pump or for intravenous administration. Consider dosage reduction or discontinuation of TZD if heart failure occurs.Hypoglycemia is the most common adverse reaction of insulin therapy, including Apidra Solostar, which may be serious.A reduction in the Apidra Solostar dose may be required in patients with renal or hepatic impairment. Apidra Solostar is a rapid-acting insulin analog indicated to improve glycemic control in adults with type 2 diabetes or adults and children (4 years and older) with type 1 diabetes. Apidra Solostar given by subcutaneous injection should normally be used in regimens that include a longer-acting insulin.g.Insulin pens, needles, or syringes must never be shared between patients. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant oral antidiabetic treatment. Change insulin regimens cautiously and only under medical supervision.
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